formulation and in vitro evaluation of indomethacin enzymatic colon specific tablet using biodegradable polymers

Colon Targeted Matrix Tablet of Biodegradable Swellable Polymers

The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small i...

Formulation And In Vitro Evaluation of Colon Targeted Matrix Tablets of Mebeverine Hydrochloride Using Natural Polymers

BACKGROUND: The present study focuses on the design and evaluation of colon targeted matrix tablets of Mebeverine hydrochloride using natural gums like guar gum, xanthan gum at different concentrations. This novel approach is expected to be promising drug delivery system for delivering Mebeverine HCl to the colon for its local action and thereby minimizing systemic side effects of the drug. MET...

Formulation and In vitro evaluation of colon targeted mesalazine tablet for the treatment of chronic pancreatitis

formulation and in vitro evaluation of ketoprofen gastric floating tablet

Formulation and in-vitro evaluation of floating microballoons of indomethacin.

Objective of present study involves preparation and evaluation of floating microballoons of indometacin as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of acrylic polymers (Eudragit RS100 and Eudragit S 100) as carriers. The yield of microballoons was...

Formulation and in-vitro evaluation of microbially triggered colon specific drug delivery using sesbania gum

The aim of the present study is to develop colon targeted drug delivery systems for metronidazole using sesbania gum as a carrier. Matrix, enteric coated and compression coated tablets of metronidazole containing various proportions of sesbania gum were prepared. All the formulations were evaluated for the hardness, drug content uniformity, and were subjected to in vitro drug release studies. M...